Research Use Only. Not for human or veterinary use.
Nexaflow Research
Vial of lyophilised MOTS-c, 10 mg

MOTS-c

A 16-amino-acid peptide encoded within the mitochondrial 12S rRNA region.

A subject of published research into mitochondrial-derived peptide signalling, AMPK activation and metabolic regulation in preclinical models.

Research Use Only. Not for human or veterinary use.

These materials are supplied to laboratories and research organisations as reagents. They are not medicines, are not supplied for administration to humans or animals, and must not be resold for those purposes.

In stock · lot A2926047 · 99.43% purity by HPLC · view certificate

Dispatched within 2 working days · tracked UK delivery · no account needed

£34.99£27.99 · £2.80/mg

Specification

Molecular formula
C101H152N28O22S2
Molecular weight
2174.6 g/mol
Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg16 residues
Purity
≥98% (HPLC)
Appearance
White lyophilised powder
Storage
Store at -20°C, protected from light and moisture.

Standard specification for this compound. The values measured for each lot are on its certificate of analysis.

In the literature

  1. Integrative transcriptomic and computational analysis associates Ms4a6c+ macrophages with fibrosis in radiation proctitis and computationally nominates MOTS-c as a candidate modulator

    Wang P, et al · Frontiers in immunology · 2026

    PMID 42952740doi:10.3389/fimmu.2026.1907084

  2. Associations of Serum MOTS-c with Exercise Capacity and Antioxidant Markers in Young Males: A Cross-Sectional Study

    Zhang Z, et al · Antioxidants (Basel, Switzerland) · 2026

    PMID 42939841doi:10.3390/antiox15101267

  3. MOTS-c attenuates placental vascular endothelial cell apoptosis in intrahepatic cholestasis of pregnancy by inhibiting K33-linked deubiquitination of BACH1

    Li S, et al · Cell communication and signaling : CCS · 2026

    PMID 42934731doi:10.1186/s12964-026-03109-2

  4. Mots-c attenuates diabetic nephropathy by downregulating LARS1 to promote lipophagy and suppress tubular senescence

    Wang J, et al · Biochemical pharmacology · 2026

    PMID 42918312doi:10.1016/j.bcp.2026.118572

  5. Mitochondrial-derived peptides in female reproduction: Emerging regulators of oocyte competence and novel therapeutic opportunities for infertility

    Rostami Z, et al · Tissue & cell · 2026

    PMID 42880137doi:10.1016/j.tice.2026.104044

  6. MOTS-c mediates remote ischemic preconditioning-induced protection against lung ischemia-reperfusion injury via NRF2-dependent mitochondrial biogenesis

    Sun J, et al · Chinese medical journal · 2026

    PMID 42767971doi:10.1097/CM9.0000000000004254

  7. Mitokines as bioenergetic stress signals in cardiovascular disease: mitochondrial communication, endocrine adaptation, and translational implications

    Kurian GA · Journal of bioenergetics and biomembranes · 2026

    PMID 42734848doi:10.1007/s10863-026-10136-8

  8. AGEs-RAGE Axis and Mitochondrial-Derived Peptides in Advanced Chronic Kidney Disease: Interconnected Pathways Beyond Inflammation and Nutrition

    Suliman ME, et al · Antioxidants (Basel, Switzerland) · 2026

    PMID 42650220doi:10.3390/antiox15080956

  9. The mitochondrial-derived peptide MOTS-c improves bioenergetics in aging-associated granulosa cells and oocytes

    Tsui KH, et al · Reproduction & fertility · 2026

    PMID 42895211doi:10.1530/RAF-26-0161

  10. Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards

    Willis J, Vu N · International journal of pharmaceutical compounding · 2026

    PMID 42752426

  11. Mitochondrial-derived peptides (MDPs) activated by physical exercise as therapeutic targets for metabolic disorders: A systematic review

    Ayubi N, et al · Physiology international · 2026

    PMID 42640735doi:10.1556/2060.2026.00863

  12. Correction: Reduced serum and skeletal muscle MOTS c levels in women with polycystic ovary syndrome are associated with mitochondrial dysfunction

    Kutuk IS, et al · Scientific reports · 2026

    PMID 42716952doi:10.1038/s41598-026-70401-z

  13. Mitochondria-Endoplasmic Reticulum Crosstalk in Pancreatic β-Cell Stress: A Driver of Diabetes

    Niinuma SA, et al · Cells · 2026

    PMID 42882431doi:10.3390/cells15191733

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